Slc39a4 - solute carrier family 39 (zinc transporter), member 4 Gene

Also Known as ZIP4; AWMS2; 1600025H15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72027

Summary

Enables zinc ion transmembrane transporter activity. Acts upstream of or within cellular response to zinc ion starvation; cellular zinc ion homeostasis; and zinc ion transport. Located in apical plasma membrane and endosome. Is expressed in several structures, including alimentary system; early embryo; extraembryonic component; genitourinary system; and integumental system. Used to study acrodermatitis enteropathica. Human ortholog(s) of this gene implicated in acrodermatitis enteropathica. Orthologous to human SLC39A4 (solute carrier family 39 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc39a4 Products (1)

mRNA Protein Name
NM_028064.3 NP_082340.1 zinc transporter ZIP4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
30593504 MGI
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
14612438 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to zinc ion starvation IDA
IDA: Inferred from direct assay
15358787 MGI
involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
12801924 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12801924 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14612438 MGI
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
14612438 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc transporter ZIP4

  • activated in W/Wv mouse stomach 2

  • zrt- and Irt-like protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13235 SLC39A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18883 Slc39a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25374 Slc39a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc39a4 NCBI NCBI:55630