Dhx36 - DEAH (Asp-Glu-Ala-His) box polypeptide 36 Gene

Also Known as RHAU; Ddx36; mKIAA1488; 2810407E23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 72162

Summary

Enables DNA helicase activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including G-quadruplex DNA unwinding; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytosol. Is expressed in heart and telencephalon. Orthologous to human DHX36 (DEAH-box helicase 36). [provided by Alliance of Genome Resources, Apr 2022]

Dhx36 Products (1)

mRNA	Protein	Name
NM_028136.2	NP_082412.2	ATP-dependent DNA/RNA helicase DHX36

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA helicase activity	IMP IMP: Inferred from mutant phenotype	25611385	MGI
enables G-quadruplex DNA binding	IDA IDA: Inferred from direct assay	25611385	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25611385	MGI
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21703541	MGI
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	21590736	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21590736	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21590736	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G-quadruplex DNA unwinding	IDA IDA: Inferred from direct assay	25611385	MGI
involved in ossification	IMP IMP: Inferred from mutant phenotype	21590736	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21703541	MGI
involved in positive regulation of cardioblast differentiation	IMP IMP: Inferred from mutant phenotype	26489465	MGI
involved in positive regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	22422825	MGI
involved in positive regulation of myeloid dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	21703541	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21590736	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25611385	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	22422825	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21703541	MGI
acts upstream of or within response to virus	IMP IMP: Inferred from mutant phenotype	21703541	MGI
involved in spermatogenesis	IDA IDA: Inferred from direct assay	25611385	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	21703541	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-dependent DNA/RNA helicase DHX36	ATP-dependent RNA helicase DHX36 DEAD/H box polypeptide 36 DEAH box protein 36 MLE-like protein 1 RNA helicase associated with AU-rich element ARE probable ATP-dependent RNA helicase DHX36

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181850	Telomeric G4s ligand 2		/	Unkown
HY-RS03755	DHX36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185723	rG4 WT_AHPC_PEG2		99.80%	Unkown
HY-185724	rG4 mut_AHPC_PEG2	Control	96.87%	Unkown
HY-RS19675	Dhx36 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26168	Dhx36 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dhx36	NCBI	NCBI:170506