Pan3 - PAN3 poly(A) specific ribonuclease subunit Gene

Also Known as 2700050F09Rik; A430027N15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72587

Summary

Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Apr 2022]

Pan3 Products (2)

mRNA Protein Name
NM_001359433.1 NP_001346362.1 PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2
NM_028291.5 NP_082567.3 PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18625844 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
IMP: Inferred from mutant phenotype
18625844 MGI
acts upstream of or within positive regulation of cytoplasmic mRNA processing body assembly IDA
IDA: Inferred from direct assay
18625844 MGI
acts upstream of or within positive regulation of cytoplasmic mRNA processing body assembly IMP
IMP: Inferred from mutant phenotype
18625844 MGI
acts upstream of or within protein targeting IDA
IDA: Inferred from direct assay
18625844 MGI
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
18625844 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PAN2-PAN3 deadenylation complex subunit Pan3

  • PAB-dependent poly(A)-specific ribonuclease subunit 3

  • PAB1P-dependent poly(A)-specific ribonuclease

  • PAN3 polyA specific ribonuclease subunit homolog

  • Pabp-dependent poly(A) nuclease 3

  • Pabp1-dependent poly A-specific ribonuclease subunit Pan3

  • poly(A)-n

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09362 NLRP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10015 PAN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18148 Pan3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24623 Pan3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pan3 NCBI NCBI:255967