2. Gene
  3. UBE2V1 - ubiquitin conjugating enzyme E2 V1 Gene

UBE2V1 - ubiquitin conjugating enzyme E2 V1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1

Gene ID: 7335 | Gene type: protein coding

About UBE2V1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,081,124-50,115,957 (from NCBI)

This gene has 23 transcripts (splice variants), 118 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues.

Summary

Ubiquitin-conjugating E2 Enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

UBE2V1 Products(17)

mRNA Protein Name
NM_001032288.3 NP_001027459.1 ubiquitin-conjugating enzyme E2 variant 1 isoform d
NM_001257393.2 NP_001244322.1 ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_001257394.2 NP_001244323.1 ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_001257395.2 NP_001244324.1 ubiquitin-conjugating enzyme E2 variant 1 isoform e
NM_001257396.2 NP_001244325.1 ubiquitin-conjugating enzyme E2 variant 1 isoform f
NM_001257397.2 NP_001244326.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257398.2 NP_001244327.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257399.2 NP_001244328.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282575.3 NP_001269504.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282576.2 NP_001269505.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282577.3 NP_001269506.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282578.3 NP_001269507.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282579.2 NP_001269508.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282580.2 NP_001269509.1 ubiquitin-conjugating enzyme E2 variant 1 isoform i
NM_021988.6 NP_068823.2 ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_022442.6 NP_071887.1 ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_199144.3 NP_954595.1 ubiquitin-conjugating enzyme E2 variant 1 isoform a

UBE2V1 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (36 - 133)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 variant 1

DNA-binding protein

Recombinant UBE2V1 Proteins

Cat. No. Product Name Accession Purity
HY-P71410 UBE2V1 Protein, Human (His) Q13404 (A2-N147) ≥95%

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Lidocaine Allergy

Lidoderm Allergy

Lignocaine Allergy

Xylocaine Allergy
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15364 UBE2V1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2V1 MGD MGI:1913839
Canis familiaris UBE2V1 VGNC VGNC:54739
Bos taurus UBE2V1 VGNC VGNC:106432
Rattus norvegicus UBE2V1 RGD RGD:1305503
Others UBE2V1 NCBI