UBE2V1 - ubiquitin conjugating enzyme E2 V1 Gene

Also Known as CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7335

About UBE2V1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,081,124-50,115,957 (from NCBI)

This gene has 23 transcripts (splice variants), 118 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues.

Summary

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to Other ubiquitin-conjugating Enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

UBE2V1 Products (17)

mRNA Protein Name
NM_001032288.3 NP_001027459.1 ubiquitin-conjugating enzyme E2 variant 1 isoform d
NM_001257393.2 NP_001244322.1 ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_001257394.2 NP_001244323.1 ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_001257395.2 NP_001244324.1 ubiquitin-conjugating enzyme E2 variant 1 isoform e
NM_001257396.2 NP_001244325.1 ubiquitin-conjugating enzyme E2 variant 1 isoform f
NM_001257397.2 NP_001244326.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257398.2 NP_001244327.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257399.2 NP_001244328.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282575.3 NP_001269504.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282576.2 NP_001269505.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282577.3 NP_001269506.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282578.3 NP_001269507.1 ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282579.2 NP_001269508.1 ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282580.2 NP_001269509.1 ubiquitin-conjugating enzyme E2 variant 1 isoform i
NM_021988.6 NP_068823.2 ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_022442.6 NP_071887.1 ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_199144.3 NP_954595.1 ubiquitin-conjugating enzyme E2 variant 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16129784 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
16129784 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
16129784 GOA
involved in positive regulation of intracellular signal transduction IDA
IDA: Inferred from direct assay
11057907 GOA
involved in positive regulation of protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
11057907 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
16307917 GOA
Cellular Component GO Annotation Evidence References Source
part of UBC13-MMS2 complex IDA
IDA: Inferred from direct assay
16307917 GOA
part of UBC13-MMS2 complex IPI
IPI: Inferred from physical interaction
11057907 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16129784 GOA
located in cytosol IDA
IDA: Inferred from direct assay
16129784 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
22797923 GOA
part of ubiquitin conjugating enzyme complex IDA
IDA: Inferred from direct assay
16129784 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16307917 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2V1 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (36 - 133)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 variant 1

  • DNA-binding protein

Recombinant UBE2V1 Proteins

Cat. No. Product Name Accession Purity
HY-P71410 UBE2V1 Protein, Human (His) Q13404 (A2-N147) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Lidocaine Allergy

  • Lidoderm Allergy

  • Lignocaine Allergy

  • Xylocaine Allergy
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15364 UBE2V1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20204 Ube2v1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26708 Ube2v1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2V1 MGD MGI:1913839
Canis familiaris UBE2V1 VGNC VGNC:54739
Bos taurus UBE2V1 VGNC VGNC:106432
Rattus norvegicus UBE2V1 RGD RGD:1305503
Others UBE2V1 NCBI