Atp13a2 - ATPase type 13A2 Gene

Predicted to enable ABC-type polyamine transporter activity; phosphatidic acid binding activity; and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including autophagosome-lysosome fusion; positive regulation of exosomal secretion; and zinc ion homeostasis. Located in neuron projection; neuronal cell body; and vesicle membrane. Is expressed in alimentary system; eye; genitourinary system; nervous system; and skin. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human ATP13A2 (ATPase cation transporting 13A2). [provided by Alliance of Genome Resources, Apr 2022]