Kmt2b - lysine (K)-specific methyltransferase 2B Gene

Also Known as Mll2; Wbp7; mKIAA0304; 2610014H22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75410

Summary

Predicted to enable Histone Methyltransferase activity (H3-K4 specific); unmethylated CpG binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including DNA methylation-dependent heterochromatin assembly; female gamete generation; and histone H3-K4 trimethylation. Predicted to be located in nucleus. Predicted to be part of Histone Methyltransferase complex. Is expressed in several structures, including alimentary system; inner cell mass; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2b Products (2)

mRNA Protein Name
NM_001290573.1 NP_001277502.1 histone-lysine N-methyltransferase 2B isoform 1
NM_029274.2 NP_083550.2 histone-lysine N-methyltransferase 2B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
33766931 MGI
enables histone H3K4 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
20808952 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
20808952 MGI
acts upstream of or within maternal-to-zygotic transition of gene expression IMP
IMP: Inferred from mutant phenotype
20808952 MGI
acts upstream of or within oocyte development IMP
IMP: Inferred from mutant phenotype
20808952 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
20808952 MGI
acts upstream of or within ovulation IMP
IMP: Inferred from mutant phenotype
20808952 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase 2B

  • WBP-7

  • WW domain binding protein 7

  • histone-lysine N-methyltransferase MLL4

  • lysine N-methyltransferase 2B

  • mixed lineage leukemia 2

  • myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog

  • trithorax homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07402 KMT2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17767 Kmt2d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20975 Kmt2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27492 Kmt2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmt2b NCBI NCBI:9757