Slc38a3 - solute carrier family 38, member 3 Gene

Also Known as Sn1; Nat1; mNAT; Snat3; D9Ucla2; Slc38-3; 0610012J02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76257

Summary

Enables L-glutamine transmembrane transporter activity and L-histidine transmembrane transporter activity. Acts upstream of or within amino acid transport; cellular response to potassium ion starvation; and positive regulation of transcription from RNA polymerase II promoter in response to acidic pH. Located in apical plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system; metanephros; pancreas; pericardium; and retina. Orthologous to human SLC38A3 (solute carrier family 38 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc38a3 Products (3)

mRNA Protein Name
NM_001199217.1 NP_001186146.1 sodium-coupled neutral amino acid transporter 3
NM_001199218.1 NP_001186147.1 sodium-coupled neutral amino acid transporter 3
NM_023805.3 NP_076294.2 sodium-coupled neutral amino acid transporter 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-asparagine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
16249471 MGI
enables L-glutamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10716701 MGI
enables L-glutamine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
16249471 MGI
enables L-histidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10716701 MGI
enables L-histidine, sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
15899884 MGI
Biological Process GO Annotation Evidence References Source
involved in L-glutamine import across plasma membrane IDA
IDA: Inferred from direct assay
18689705 MGI
involved in L-histidine import across plasma membrane IDA
IDA: Inferred from direct assay
15899884 MGI
acts upstream of or within cellular response to potassium ion starvation IDA
IDA: Inferred from direct assay
19458124 MGI
involved in glutamine secretion IDA
IDA: Inferred from direct assay
29561757 MGI
acts upstream of or within glutamine transport IDA
IDA: Inferred from direct assay
10716701 MGI
acts upstream of or within histidine transport IDA
IDA: Inferred from direct assay
10716701 MGI
involved in intracellular amino acid homeostasis IMP
IMP: Inferred from mutant phenotype
26490457 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19458124 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
32046769 MGI
located in membrane IDA
IDA: Inferred from direct assay
19458124 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10716701 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium-coupled neutral amino acid transporter 3

  • N system amino acids transporter NAT-1

  • N-system amino acid transporter 1

  • Na(+)-coupled neutral amino acid transporter 3

  • system N amino acid transporter 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13221 SLC38A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22043 Slc38a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc38a3 NCBI NCBI:10991