Knl1 - kinetochore scaffold 1 Gene

Also Known as Casc5; 2310043D08Rik; 5730505K17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76464

Summary

Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in acrosomal vesicle; kinetochore; and nuclear body. Predicted to be active in nucleus. Is expressed in telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 4. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Apr 2022]

Knl1 Products (2)

mRNA Protein Name
NM_001362732.1 NP_001349661.1 kinetochore scaffold 1 isoform 2
NM_029617.3 NP_083893.2 kinetochore scaffold 1 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in homologous chromosome orientation in meiotic metaphase I IMP
IMP: Inferred from mutant phenotype
35167144 MGI
involved in positive regulation of meiosis I spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
35167144 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
35167144 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
35167144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinetochore scaffold 1

  • cancer susceptibility candidate 5

  • kinetochore-null protein 1

  • protein CASC5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07412 KNL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116470 Mps1/TTK-IN-1 Inhibitor / Unkown
HY-RS22214 Knl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28736 Knl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Knl1 NCBI NCBI:57082