IL1R2 - interleukin 1 receptor type 2 Gene

Also Known as IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7850

About IL1R2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,991,960-102,028,544 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 10 paralogues. Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three Other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

IL1R2 Products (2)

mRNA Protein Name
NM_001261419.2 NP_001248348.1 interleukin-1 receptor type 2 isoform 2 precursor
NM_004633.4 NP_004624.1 interleukin-1 receptor type 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
1830582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1R2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (42 - 116)

Ig_2

Ig_2: Immunoglobulin domain (137 - 220)

ig

ig: Immunoglobulin domain (251 - 328)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor type 2

  • CD121 antigen-like family member B

Recombinant IL1R2 Proteins

Cat. No. Product Name Accession Purity
HY-P72567 IL-1R2 Protein, Human (HEK293, His) P27930/NP_004624.1 (F14-E343) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75849 IL-1R2 Protein, Human (HEK293) P27930 (F14-E343) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77701 IL-1R2 Protein, Human (HEK293, Fc) P27930 (F14-E343) ≥ 95%, as determined by Bis-Tris PAGE.

IL1R2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84231 CD121B Antibody (YA3928) WB, FC, ELISA Human
HY-P84231A CD121B Antibody (YA3928)(PBS only) WB, FC, ELISA Human
HY-P84232 CD121B Antibody (YA3929) ICC/IF, FC, ELISA Human
HY-P84232A CD121B Antibody (YA3929)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Endometriosis

  • Endometriosis, Site Unspecified

  • Endometrial Ectopia
Mastitis

  • Breast Inflammation

  • Inflammatory Breast Disease

  • Inflammatory Disease Of Breast

  • Inflammation Of Non-Human Mammary Gland

  • Inflammatory Disorder Of Breast

  • Mastitis Nos

  • Acute Mastitis Nos

  • Acute Nonpuerperal Mastitis

  • Nonpuerperal Mastitis Nos

  • Subacute Mastitis Nos
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171657 4'-Acetoxy resveratrol 99.90% Unkown
HY-RS06721 IL1R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19694 Il1r2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26189 Il1r2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL1R2 VGNC VGNC:30132
Canis familiaris IL1R2 VGNC VGNC:41959
Rattus norvegicus IL1R2 RGD RGD:621147
Mus musculus IL1R2 MGD MGI:96546
Felis catus IL1R2 VGNC VGNC:67767
Macaca mulatta IL1R2 VGNC VGNC:73717
Others IL1R2 NCBI