Slc6a1 - solute carrier family 6 member 1 Gene

Also Known as Gat1; Gabt1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79212

Summary

Enables gamma-aminobutyric acid:sodium symporter activity and identical protein binding activity. Involved in several processes, including gamma-aminobutyric acid import; negative regulation of GABAergic synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Located in cell surface; neuron projection; and plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study brain ischemia. Biomarker of cerebral infarction; epilepsy; temporal lobe epilepsy; and withdrawal disorder. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a1 Products (1)

mRNA Protein Name
NM_024371.3 NP_077347.1 sodium- and chloride-dependent GABA transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
1975955 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16314925 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11017172 RGD
Biological Process GO Annotation Evidence References Source
involved in gamma-aminobutyric acid import IDA
IDA: Inferred from direct assay
16378241 RGD
involved in learning IMP
IMP: Inferred from mutant phenotype
12110474 RGD
involved in negative regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17317750 RGD
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
1975955 RGD
involved in neurotransmitter reuptake IMP
IMP: Inferred from mutant phenotype
1975955 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
14500747 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
15778221 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
12832547 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15664431 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
15149801 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
30275762 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17408599 RGD
involved in response to purine-containing compound IMP
IMP: Inferred from mutant phenotype
16730753 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
15778221 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
14500747 RGD
involved in response to toxic substance IMP
IMP: Inferred from mutant phenotype
14643747 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
24368619 RGD
located in cell surface IDA
IDA: Inferred from direct assay
14500747 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
24368619 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24368619 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent GABA transporter 1

  • GABA transporter protein

  • GAT-1

  • solute carrier family 6 (neurotransmitter transporter), member 1

  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13296 SLC6A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21939 Slc6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28456 Slc6a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a1 NCBI NCBI:6529