ADAM33 - ADAM metallopeptidase domain 33 Gene

Homo sapiens

Also known as C20orf153; DJ964F7.1

Gene ID: 80332 | Gene type: protein coding

About ADAM33

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,667,975-3,682,010 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

ADAM33 Products(3)

mRNA	Protein	Name
NM_001282447.3	NP_001269376.1	disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor
NM_025220.5	NP_079496.1	disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein
NM_153202.4	NP_694882.1	disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

ADAM33 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
813 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 33

ADAM 33

Related Diseases

Diseases

Alias

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Near-Fatal Asthma

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Intrinsic Asthma

Non-Atopic Asthma

Chronic Asthma

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00284	ADAM33 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADAM33	VGNC	VGNC:59583
Rattus norvegicus	ADAM33	RGD	RGD:1305278
Macaca mulatta	ADAM33	VGNC	VGNC:69409
Canis familiaris	ADAM33	VGNC	VGNC:37585
Mus musculus	ADAM33	MGD	MGI:1341813
Bos taurus	ADAM33	VGNC	VGNC:25611
Others	ADAM33	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.