Dhx58 - DEXH (Asp-Glu-X-His) box polypeptide 58 Gene

Also Known as LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80861

Summary

Enables double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]

Dhx58 Products (1)

mRNA Protein Name
NM_030150.2 NP_084426.2 ATP-dependent RNA helicase DHX58

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21703541 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of RIG-I signaling pathway IMP
IMP: Inferred from mutant phenotype
17475874 MGI
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
21525357 MGI
involved in negative regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
21525357 MGI
involved in positive regulation of MDA-5 signaling pathway IMP
IMP: Inferred from mutant phenotype
20080593 MGI
involved in positive regulation of RIG-I signaling pathway IMP
IMP: Inferred from mutant phenotype
20080593 MGI
involved in positive regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
20080593 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in response to virus IMP
IMP: Inferred from mutant phenotype
20080593 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11735219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

  • ATP-dependent helicase LGP2

  • RIG-I-like receptor 3

  • RIG-I-like receptor Lgp2

  • RLR

  • RNA helicase LGP2

  • probable ATP-dependent helicase LGP2

  • protein D11Lgp2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03759 DHX58 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21554 Dhx58 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28072 Dhx58 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhx58 NCBI NCBI:79132