CHRM2 - Chrm2 cholinergic receptor, muscarinic 2 Gene

Also Known as Acm2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81645

Summary

Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of smooth muscle contraction. Located in several cellular components, including asymmetric synapse; neuronal cell body; and symmetric synapse. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Apr 2022]

CHRM2 Products (1)

mRNA Protein Name
NM_031016.2 NP_112278.2 muscarinic acetylcholine receptor M2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled acetylcholine receptor activity IDA
IDA: Inferred from direct assay
12534975 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
12534975 RGD
involved in regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
12185001 RGD
Cellular Component GO Annotation Evidence References Source
located in asymmetric synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8182478 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8182478 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8182478 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
8182478 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8182478 RGD
located in symmetric synapse IDA
IDA: Inferred from direct assay
8182478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M2

  • 7TM receptor

  • M2 muscarinic acetylcholine receptor

  • cholinergic receptor, muscarinic 2, cardiac

  • muscarinic acetylcholine receptor M2-like

  • muscarinic receptor m2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N8728 Aposcopolamine 98.23% Unkown
HY-RS02661 CHRM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19417 Chrm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25908 Chrm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CHRM2 NCBI NCBI:1129