Jdp2 - Jun dimerization protein 2 Gene

Also Known as TIF; Jundm2; Jundp2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 81703

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Acts upstream of or within with a negative effect on regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of fat cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of histone deacetylation. Located in nucleus. Is expressed in several structures, including blood island; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Jdp2 Products (4)

mRNA	Protein	Name
NM_001205052.2	NP_001191981.1	jun dimerization protein 2
NM_001205053.2	NP_001191982.1	jun dimerization protein 2
NM_001401266.1	NP_001388195.1	jun dimerization protein 2
NM_030887.3	NP_112149.2	jun dimerization protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11231009	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11231009	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11231009	MGI
enables cAMP response element binding	IDA IDA: Inferred from direct assay	11231009	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17464331	MGI
enables histone chaperone activity	IGI IGI: Inferred from genetic interaction	17464331	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17464331	MGI
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	11231009	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11231009	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11231009	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11231009	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within chromatin remodeling	IGI IGI: Inferred from genetic interaction	17464331	MGI
acts upstream of fat cell differentiation	IDA IDA: Inferred from direct assay	17464331	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	17464331	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11231009	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11231009	MGI
acts upstream of or within negative effect regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11231009	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17464331	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
jun dimerization protein 2	c-Jun dimerization protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07034	JDP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19907	Jdp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26408	Jdp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jdp2	NCBI	NCBI:122953