2. Gene
  3. Tgfb2 - transforming growth factor, beta 2 Gene

Tgfb2 - transforming growth factor, beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as TGF-B2

Gene ID: 81809 | Gene type: protein coding

About Tgfb2

Primary_assembly 13: 98,160,087-98,261,405 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 199 orthologues, 31 paralogues and is associated with 45 phenotypes. Biased expression in Lung (RPKM 13.), Muscle (RPKM 77.3) and 9 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal Cancer. Orthologous to human TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb2 Products(1)

mRNA Protein Name
NM_031131.2 NP_112393.2 transforming growth factor beta-2 proprotein precursor

Tgfb2 Protein Structure

TGFb_propeptide

TGFb_propeptide: pfam00688 (20 - 255)

TGF_beta_TGFB2

TGF_beta_TGFB2: cd19385 (344 - 440)

  • 0
  • 100
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  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta-2 proprotein

TGF beta 2 protein

TGF-beta-2

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990009 Nisevokitug Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14439 TGFB2 Human Pre-designed siRNA Set A / Unkown
HY-RS14440 Tgfb2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14441 Tgfb2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb2 NCBI NCBI:7042
Canis familiaris Tgfb2 NCBI NCBI:488596
Mus musculus Tgfb2 NCBI NCBI:21808
Macaca mulatta Tgfb2 NCBI NCBI:707540