Tgfb2 - transforming growth factor, beta 2 Gene

Also Known as TGF-B2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81809

About Tgfb2

Primary_assembly 13: 98,160,087-98,261,405 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 199 orthologues, 31 paralogues and is associated with 45 phenotypes. Biased expression in Lung (RPKM 13.), Muscle (RPKM 77.3) and 9 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal Cancer. Orthologous to human TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb2 Products (1)

mRNA Protein Name
NM_031131.2 NP_112393.2 transforming growth factor beta-2 proprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18406405 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18406405 RGD
Biological Process GO Annotation Evidence References Source
involved in digestive tract development IEP
IEP: Inferred from expression pattern
12815632 RGD
involved in embryonic neurocranium morphogenesis IDA
IDA: Inferred from direct assay
11002343 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
15927076 RGD
involved in frontal suture morphogenesis IEP
IEP: Inferred from expression pattern
12416537 RGD
involved in hindbrain development IEP
IEP: Inferred from expression pattern
11231055 RGD
involved in inner ear development IEP
IEP: Inferred from expression pattern
16479080 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
11245570 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
11002343 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15944186 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
12876066 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
16479313 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16532270 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
11014222 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11002343 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
15899155 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15746252 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
12130550 RGD
involved in response to laminar fluid shear stress IEP
IEP: Inferred from expression pattern
16217485 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
16479313 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
11956143 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15746252 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
16439574 RGD
involved in thyroid gland development IEP
IEP: Inferred from expression pattern
18554691 RGD
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
16479080 RGD
located in cell surface IDA
IDA: Inferred from direct assay
12595240 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12595240 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
12595240 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12595240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb2 Protein Structure

TGFb_propeptide

TGFb_propeptide: pfam00688 (20 - 255)

TGF_beta_TGFB2

TGF_beta_TGFB2: cd19385 (344 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta-2 proprotein

  • TGF beta 2 protein

  • TGF-beta-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14439 TGFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14440 Tgfb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14441 Tgfb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174533 Human TGFB2 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb2 NCBI NCBI:7042