NCOA2 - Ncoa2 nuclear receptor coactivator 2 Gene

Also Known as Tif2; Grip1; GRIP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83724

Summary

Enables DNA Polymerase binding activity; PDZ domain binding activity; and nuclear receptor binding activity. Involved in several processes, including male gonad development; positive regulation of female receptivity; and positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including dendritic spine; postsynaptic density; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

NCOA2 Products (1)

mRNA Protein Name
NM_031822.2 NP_114010.2 nuclear receptor coactivator 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA polymerase binding IPI
IPI: Inferred from physical interaction
11734998 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
20678994 RGD
enables nuclear glucocorticoid receptor binding IPI
IPI: Inferred from physical interaction
9742117 RGD
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
9742117 RGD
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
9742117 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15234273 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
10803578 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
16189181 RGD
involved in positive regulation of female receptivity IMP
IMP: Inferred from mutant phenotype
12089347 RGD
involved in positive regulation of glucocorticoid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17481888 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17481888 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
31272713 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
11007883 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 2

  • NCoA-2

  • glucocorticoid receptor interacting protein 1

  • transcriptional intermediary factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173033 MI-883 99.57% Unkown
HY-RS09090 NCOA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19721 Ncoa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26217 Ncoa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NCOA2 NCBI NCBI:10499