Prkci - protein kinase C, iota Gene

Also Known as Pkcl

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84006

About Prkci

Primary_assembly 2: 112,321,929-112,382,352 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 228 orthologues, 9 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 259.4), Kidney (RPKM 161.9) and 9 other tissues.

Summary

Predicted to enable phospholipid binding activity and protein kinase C activity. Involved in several processes, including Golgi vesicle budding; cellular response to Insulin stimulus; and response to interleukin-1. Located in cell leading edge; cytosol; and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Colocalizes with bicellular tight junction. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]

Prkci Products (1)

mRNA	Protein	Name
NM_032059.1	NP_114448.1	protein kinase C iota type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19885391	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi vesicle budding	IDA IDA: Inferred from direct assay	12871960	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19885391	RGD
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	12975478	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	23511975	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	23511975	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	23511975	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	23511975	RGD
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	19782155	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	15649420	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	23511975	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	23511975	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	23511975	RGD
located in bicellular tight junction	IDA IDA: Inferred from direct assay	9763423	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	19885391	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23511975	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23511975	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23511975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkci Protein Structure

PB1_aPKC

C1_aPKC

STKc_aPKC_iota

0
100
200
300
400
500
596 a.a.

Protein Preferred Names	Protein Names
protein kinase C iota type	aPKC-lambda/iota atypical protein kinase C-lambda/iota nPKC-iota protein kinase C, lambda

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11134	PRKCI Human Pre-designed siRNA Set A		/	Unkown
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28112	Hint1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkci	NCBI	NCBI:5584