C3ar1 - complement C3a receptor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84007

Summary

Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Located in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

C3ar1 Products (1)

mRNA Protein Name
NM_032060.2 NP_114449.2 C3a anaphylatoxin chemotactic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables complement component C3a binding IDA
IDA: Inferred from direct assay
9464274 RGD
enables complement component C3a receptor activity IDA
IDA: Inferred from direct assay
9464274 RGD
enables complement component C3a receptor activity IPI
IPI: Inferred from physical interaction
9464274 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
23713944 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18635264 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
15292245 RGD
involved in positive regulation of glomerular mesangial cell proliferation IMP
IMP: Inferred from mutant phenotype
23713944 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22089112 RGD
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
19285573 RGD
involved in tolerance induction to nonself antigen IMP
IMP: Inferred from mutant phenotype
12514742 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C3a anaphylatoxin chemotactic receptor

  • C3AR

  • C3a-R

  • complement component 3a receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1345A TLQP-21 TFA Agonist 99.90% Unkown
HY-RS21501 C3ar1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P1345 TLQP-21 Agonist / Unkown
HY-RS01744 C3AR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28019 C3ar1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C3ar1 NCBI NCBI:719