Dll1 - delta like canonical Notch ligand 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84010

Summary

Enables Notch binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Notch signaling pathway. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Dll1 Products (2)

mRNA Protein Name
NM_032063.3 NP_114452.2 delta-like protein 1 precursor
NM_032063.3 NP_114452.2 delta-like protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Notch binding IPI
IPI: Inferred from physical interaction
10079256 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22658936 RGD
Biological Process GO Annotation Evidence References Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
22658936 RGD
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
22658936 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-like protein 1

  • delta1

  • drosophila Delta homolog 1

Recombinant Dll1 Proteins

Cat. No. Product Name Accession Purity
HY-P72971 Delta-like protein 1/DLL1 Protein, Rat (HEK293, Fc) EDL99825.1 (S22-S534) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75295 Delta-like protein 1/DLL1 Protein, Rat (HEK293, His) P97677 (Q18-S534) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990077 Pidilizumab Inhibitor 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182008 NEURL1B-IN-1 / Unkown
HY-RS03808 DLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16910 Dll1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23352 Dll1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990253 Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dll1 NCBI NCBI:28514
Mus musculus Dll1 NCBI NCBI:13388