Enpp2 - ectonucleotide pyrophosphatase/phosphodiesterase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84050

Summary

Enables lysophospholipase activity; metal ion binding activity; and phosphoric diester hydrolase activity. Involved in several processes, including cellular response to estradiol stimulus; estrous cycle; and regulation of cell-substrate adhesion. Located in Golgi apparatus and extracellular space. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]

Enpp2 Products (1)

mRNA Protein Name
NM_057104.3 NP_476445.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alkylglycerophosphoethanolamine phosphodiesterase activity IDA
IDA: Inferred from direct assay
24747415 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
21240271 RGD
enables lysophospholipase activity IDA
IDA: Inferred from direct assay
12354767 RGD
enables phosphodiesterase I activity IMP
IMP: Inferred from mutant phenotype
17307740 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
21240271 RGD
Biological Process GO Annotation Evidence References Source
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
17307740 RGD
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
24361405 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
18946176 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
22122904 RGD
involved in negative regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
12837632 RGD
involved in phosphatidylcholine catabolic process IDA
IDA: Inferred from direct assay
21240271 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12119361 RGD
involved in positive regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
22139091 RGD
involved in positive regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
22139091 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
22139091 RGD
involved in response to polycyclic arene IEP
IEP: Inferred from expression pattern
25490995 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12837632 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 2

  • E-NPP 2

  • autotaxin

  • extracellular lysophospholipase D

  • lysoPLD

  • phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145344 ONO-8430506 Inhibitor 99.90% Unkown
HY-126233 PAT-347 Inhibitor 98.63% Unkown
HY-143582 ATX inhibitor 9 Inhibitor / Unkown
HY-146124 ATX inhibitor 21 Inhibitor / Unkown
HY-175478 Enpp-1-IN-27 / Unkown
HY-181667 Enpp-1-IN-30 Inhibitor / Unkown
HY-184200 Enpp-1-IN-32 / Unkown
HY-RS04388 ENPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17381 Enpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23836 Enpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp2 NCBI NCBI:5168