ZBED3 - zinc finger BED-type containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84327

About ZBED3

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:77,072,072-77,087,285 (from NCBI)

This gene has 3 transcripts (splice variants) and 51 orthologues. Ubiquitous expression in fat (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung Cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung Cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to Insulin. [provided by RefSeq, Jul 2016]

ZBED3 Products (2)

mRNA	Protein	Name
NM_001329564.2	NP_001316493.1	zinc finger BED domain-containing protein 3
NM_032367.4	NP_115743.1	zinc finger BED domain-containing protein 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in response to glucose	IDA IDA: Inferred from direct assay	24283382	GOA
involved in response to insulin	IDA IDA: Inferred from direct assay	24283382	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24283382	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBED3 Protein Structure

zf-BED

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
zinc finger BED domain-containing protein 3	2610005H11Rik

Related Diseases

Diseases	Alias
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175601	DD-04-038	Degrader	/	Unkown
HY-RS15956	ZBED3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZBED3	VGNC	VGNC:107034
Rattus norvegicus	ZBED3	RGD	RGD:1309665
Macaca mulatta	ZBED3	VGNC	VGNC:79271
Felis catus	ZBED3	VGNC	VGNC:102365
Mus musculus	ZBED3	MGD	MGI:1919364