2. Gene
  3. ADGRA1 - adhesion G protein-coupled receptor A1 Gene

ADGRA1 - adhesion G protein-coupled receptor A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPR123

Gene ID: 84435 | Gene type: protein coding

About ADGRA1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,087,924-133,131,675 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 42 paralogues. Biased expression in brain (RPKM 3.7), adrenal (RPKM 1.0) and 1 other tissue.

Summary

This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of Neuronal Signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

ADGRA1 Products(2)

mRNA Protein Name
NM_001083909.3 NP_001077378.1 adhesion G protein-coupled receptor A1 isoform 1
NM_001291085.2 NP_001278014.1 adhesion G protein-coupled receptor A1 isoform 2

ADGRA1 Protein Structure

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (22 - 302)

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  • 560 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor A1

G-protein coupled receptor 123

Related Diseases

Diseases Alias
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00342 ADGRA1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADGRA1 RGD RGD:1308241
Mus musculus ADGRA1 MGD MGI:1277167
Bos taurus ADGRA1 VGNC VGNC:55933
Canis familiaris ADGRA1 VGNC VGNC:56110
Macaca mulatta ADGRA1 VGNC VGNC:100291