ABLIM2 - actin binding LIM protein family member 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84448

About ABLIM2

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,965,327-8,158,813 (from NCBI)

This gene has 16 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in spleen (RPKM 7.8), brain (RPKM 4.6) and 16 other tissues.

Summary

Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

ABLIM2 Products (8)

mRNA Protein Name
NM_001130083.2 NP_001123555.1 actin-binding LIM protein 2 isoform 1
NM_001130084.2 NP_001123556.1 actin-binding LIM protein 2 isoform 2
NM_001130085.2 NP_001123557.1 actin-binding LIM protein 2 isoform 3
NM_001130086.2 NP_001123558.1 actin-binding LIM protein 2 isoform 4
NM_001130087.2 NP_001123559.1 actin-binding LIM protein 2 isoform 5
NM_001130088.2 NP_001123560.1 actin-binding LIM protein 2 isoform 7
NM_001286688.2 NP_001273617.1 actin-binding LIM protein 2 isoform 8
NM_032432.5 NP_115808.3 actin-binding LIM protein 2 isoform 6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26871637 GOA
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
17194709 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABLIM2 Protein Structure

LIM

LIM: LIM domain (24 - 78)

LIM

LIM: LIM domain (83 - 135)

LIM

LIM: LIM domain (153 - 208)

LIM

LIM: LIM domain (212 - 255)

VHP

VHP: Villin headpiece domain (576 - 611)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
Protein Preferred Names Protein Names

actin-binding LIM protein 2

  • abLIM-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00107 ABLIM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ABLIM2 VGNC VGNC:69474
Canis familiaris ABLIM2 VGNC VGNC:37479
Felis catus ABLIM2 VGNC VGNC:59490
Bos taurus ABLIM2 VGNC VGNC:25508
Mus musculus ABLIM2 MGD MGI:2385758
Rattus norvegicus ABLIM2 RGD RGD:1303094
Others ABLIM2 NCBI