ST6GAL2 - ST6 beta-galactoside alpha-2,6-sialyltransferase 2 Gene

Homo sapiens

Also known as SIAT2; ST6GalII

Gene ID: 84620 | Gene type: protein coding

About ST6GAL2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:106,801,600-106,887,277 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 14 paralogues. Biased expression in thyroid (RPKM 11.0), brain (RPKM 3.9) and 3 other tissues.

Summary

This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

ST6GAL2 Products(4)

mRNA	Protein	Name
NM_001142351.2	NP_001135823.1	beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_001142352.2	NP_001135824.1	beta-galactoside alpha-2,6-sialyltransferase 2 isoform b
NM_001322362.2	NP_001309291.1	beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_032528.3	NP_115917.1	beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

ST6GAL2 Protein Structure

Glyco_transf_29

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

beta-galactoside alpha-2,6-sialyltransferase 2

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2

Related Diseases

Diseases

Alias

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma	Follicular Adenocarcinoma
Follicular Adenocarcinoma, Well Differentiated	Follicular Carcinoma
Thyroid Adenocarcinoma	Adenocarcinoma, Follicular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13853	ST6GAL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ST6GAL2	VGNC	VGNC:77824
Canis familiaris	ST6GAL2	VGNC	VGNC:46857
Rattus norvegicus	ST6GAL2	RGD	RGD:1559663
Felis catus	ST6GAL2	VGNC	VGNC:65727
Bos taurus	ST6GAL2	VGNC	VGNC:35338
Mus musculus	ST6GAL2	MGD	MGI:2445190

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