ST6GAL2 - ST6 beta-galactoside alpha-2,6-sialyltransferase 2 Gene

Also Known as SIAT2; ST6GalII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84620

About ST6GAL2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:106,801,600-106,887,277 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 14 paralogues. Biased expression in thyroid (RPKM 11.0), brain (RPKM 3.9) and 3 other tissues.

Summary

This locus encodes a Sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

ST6GAL2 Products (4)

mRNA Protein Name
NM_001142351.2 NP_001135823.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_001142352.2 NP_001135824.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform b
NM_001322362.2 NP_001309291.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_032528.3 NP_115917.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
IDA: Inferred from direct assay
12235148 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in oligosaccharide metabolic process IDA
IDA: Inferred from direct assay
12235148 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST6GAL2 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (265 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

beta-galactoside alpha-2,6-sialyltransferase 2

  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2

Related Diseases

Diseases Alias
Thyroid Gland Follicular Carcinoma

  • Follicular Thyroid Carcinoma

  • Follicular Adenocarcinoma

  • Follicular Adenocarcinoma, Well Differentiated

  • Follicular Carcinoma

  • Thyroid Adenocarcinoma

  • Adenocarcinoma, Follicular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13853 ST6GAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20652 St6gal2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27163 St6gal2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ST6GAL2 VGNC VGNC:77824
Canis familiaris ST6GAL2 VGNC VGNC:46857
Rattus norvegicus ST6GAL2 RGD RGD:1559663
Felis catus ST6GAL2 VGNC VGNC:65727
Bos taurus ST6GAL2 VGNC VGNC:35338
Mus musculus ST6GAL2 MGD MGI:2445190
Others ST6GAL2 NCBI