TOX2 - TOX high mobility group box family member 2 Gene

Also Known as GCX1; GCX-1; C20orf100; dJ495O3.1; dJ1108D11.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84969

About TOX2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,914,852-44,069,616 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 20 paralogues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 4.6) and 21 other tissues.

Summary

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TOX2 Products (4)

mRNA Protein Name
NM_001098796.2 NP_001092266.1 TOX high mobility group box family member 2 isoform c
NM_001098797.2 NP_001092267.1 TOX high mobility group box family member 2 isoform a
NM_001098798.2 NP_001092268.1 TOX high mobility group box family member 2 isoform b
NM_032883.3 NP_116272.1 TOX high mobility group box family member 2 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
25352127 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25352127 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX2 Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (255 - 302)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

TOX high mobility group box family member 2

  • granulosa cell HMG box 1

Related Diseases

Diseases Alias
Conduct Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14909 TOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TOX2 VGNC VGNC:47718
Bos taurus TOX2 VGNC VGNC:55084
Felis catus TOX2 VGNC VGNC:66459
Rattus norvegicus TOX2 RGD RGD:735184
Mus musculus TOX2 MGD MGI:3611233
Macaca mulatta TOX2 VGNC VGNC:79007
Others TOX2 NCBI