IFITM1 - interferon induced transmembrane protein 1 Gene

Also Known as 9-27; CD225; IFI17; LEU13; DSPA2a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8519

About IFITM1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:314,040-315,272 (from NCBI)

This gene has 29 transcripts (splice variants), 260 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM1 Products (1)

mRNA Protein Name
NM_003641.5 NP_003632.4 interferon-induced transmembrane protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2398277 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20838853 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20838853 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
21253575 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
21253575 GOA
involved in negative regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
21976647 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22634173 GOA
involved in response to interferon-alpha IDA
IDA: Inferred from direct assay
22479637 GOA
involved in response to interferon-beta IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to type II interferon IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
21253575 GOA
Cellular Component GO Annotation Evidence References Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
26354436 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26354436 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28246125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFITM1 Protein Structure

CD225

CD225: Interferon-induced transmembrane protein (21 - 100)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

interferon-induced transmembrane protein 1

  • dispanin subfamily A member 2a

IFITM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83321 IFITM1 Antibody (YA3066) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P83321A IFITM1 Antibody (YA3066)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
West Nile Virus

  • West Nile Virus, Susceptibility To

  • Wnv

  • Wnv, Susceptibility To

  • West Nile Viral Infection

  • Encephalitis, West Nile Fever

  • West Nile Fever
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Rift Valley Fever

  • Rfv - [Rift Valley Fever]
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Inflammatory Bowel Disease 27

  • IBD27
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155815 MS9715 99.48% Unkown
HY-RS06565 IFITM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20165 Ifitm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26669 Ifitm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IFITM1 MGD MGI:1915963
Rattus norvegicus IFITM1 RGD RGD:1307601
Others IFITM1 NCBI