Polg - DNA polymerase gamma, catalytic subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85472

Summary

Enables DNA-directed DNA Polymerase activity. Involved in several processes, including cellular response to glucose stimulus; response to gamma radiation; and response to hyperoxia. Located in mitochondrion and terminal bouton. Part of gamma DNA Polymerase complex. Used to study Alpers-Huttenlocher syndrome and hepatocellular carcinoma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA Polymerase gamma, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Polg Products (1)

mRNA Protein Name
NM_053528.2 NP_445980.2 DNA polymerase subunit gamma-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
12565799 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
22743328 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
12425958 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
8786668 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
15979612 RGD
Cellular Component GO Annotation Evidence References Source
part of gamma DNA polymerase complex IDA
IDA: Inferred from direct assay
12565799 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15979612 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase subunit gamma-1

  • DNA-directed DNA polymerase gamma

  • mitochondrial DNA polymerase catalytic subunit

  • polG-alpha

  • polymerase (DNA directed), gamma

  • polymerase (DNA) gamma, catalytic subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174216 PZL-A Activator 99.72% Unkown
HY-RS10829 POLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19370 Polg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22735 Polg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25862 Polg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29249 Polg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polg NCBI NCBI:5428