2. Gene
  3. CADPS - calcium dependent secretion activator Gene

CADPS - calcium dependent secretion activator Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAPS; CAPS1; CADPS1; UNC-31

Gene ID: 8618 | Gene type: protein coding

About CADPS

Cytogenetic location: 3p14.2 Genomic coordinates (GRCh38): 3:62,398,348-62,875,416 (from NCBI)

This gene has 20 transcripts (splice variants) and 28 orthologues. Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues.

Summary

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

CADPS Products(3)

mRNA Protein Name
NM_003716.4 NP_003707.2 calcium-dependent secretion activator 1 isoform 1
NM_183393.3 NP_899630.1 calcium-dependent secretion activator 1 isoform 3
NM_183394.3 NP_899631.1 calcium-dependent secretion activator 1 isoform 2

CADPS Protein Structure

DUF1041

DUF1041: Domain of Unknown Function (DUF1041) (835 - 940)

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  • 1353 a.a.
Protein Preferred Names Protein Names

calcium-dependent secretion activator 1

CAPS-1

Related Diseases

Diseases Alias
Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor

Somatosatinoma Of Jejunum

Jejunal Somatostatin-Producing Neuroendocrine Tumor
Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

Pediatric Cns Pnet

Childhood Central Nervous System Primitive Neuroectodermal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01823 CADPS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01824 CADPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CADPS VGNC VGNC:26698
Felis catus CADPS VGNC VGNC:80014
Canis familiaris CADPS VGNC VGNC:38658
Rattus norvegicus CADPS RGD RGD:708573
Mus musculus CADPS MGD MGI:1350922