Ptch1 - patched 1 Gene

Also Known as Ptch; Ptch2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89830

Summary

Predicted to enable several functions, including Cholesterol binding activity; cyclin binding activity; and signaling receptor binding activity. Involved in several processes, including commissural neuron axon guidance; gland development; and response to estradiol. Located in growth cone; nucleus; and postsynaptic density. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptch1 Products (2)

mRNA Protein Name
NM_001389256.1 NP_001376185.1 protein patched homolog 1 isoform 2
NM_053566.3 NP_446018.1 protein patched homolog 1 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
19946319 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22024090 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
15328011 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17109907 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
16943241 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18772241 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
17307727 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18772241 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
21893610 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
21618238 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
21618238 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
21618238 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein patched homolog 1

  • patched homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10875 HL2-m5 Inhibitor 98.06% Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-153499 SMO-IN-4 Antagonist / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-RS11356 PTCH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18678 Ptch1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25164 Ptch1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptch1 NCBI NCBI:5727