ABCC10 - ATP binding cassette subfamily C member 10 Gene

Also Known as MRP7; SIMRP7; EST182763

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89845

About ABCC10

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,427,541-43,451,994 (from NCBI)

This gene has 10 transcripts (splice variants), 480 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

ABCC10 Products (3)

mRNA Protein Name
NM_001198934.2 NP_001185863.1 ATP-binding cassette sub-family C member 10 isoform MRP7
NM_001350518.2 NP_001337447.1 ATP-binding cassette sub-family C member 10 isoform 3
NM_033450.3 NP_258261.2 ATP-binding cassette sub-family C member 10 isoform MRP7A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ABC-type glutathione S-conjugate transporter activity IDA
IDA: Inferred from direct assay
23087055 GOA
enables ABC-type transporter activity IDA
IDA: Inferred from direct assay
23087055 GOA
enables ABC-type xenobiotic transporter activity IDA
IDA: Inferred from direct assay
23087055 GOA
Biological Process GO Annotation Evidence References Source
involved in leukotriene metabolic process IDA
IDA: Inferred from direct assay
23087055 GOA
involved in leukotriene transport IDA
IDA: Inferred from direct assay
23087055 GOA
Cellular Component GO Annotation Evidence References Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
35307651 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
23087055 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28112518 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCC10 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (286 - 551)

ABC_tran

ABC_tran: ABC transporter (620 - 753)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (958 - 1197)

ABC_tran

ABC_tran: ABC transporter (1263 - 1410)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1492 a.a.
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 10

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173189 2-5A Inhibitor / Unkown
HY-RS00058 ABCC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ABCC10 RGD RGD:1306696
Bos taurus ABCC10 VGNC VGNC:25469
Canis familiaris ABCC10 VGNC VGNC:37437
Mus musculus ABCC10 MGD MGI:2386976
Felis catus ABCC10 VGNC VGNC:67653
Macaca mulatta ABCC10 VGNC VGNC:81005
Others ABCC10 NCBI