UCN2 - urocortin 2 Gene

Also Known as UR; SRP; URP; UCNI; UCN-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90226

About UCN2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,561,718-48,563,781 (from NCBI)

This gene has 1 transcript (splice variant), 140 orthologues and 1 paralogue. Biased expression in skin (RPKM 5.7), endometrium (RPKM 1.2) and 4 other tissues.

Summary

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

UCN2 Products (1)

mRNA Protein Name
NM_033199.4 NP_149976.1 urocortin-2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables corticotropin-releasing hormone receptor binding IPI
IPI: Inferred from physical interaction
11329063 GOA
enables hormone binding IPI
IPI: Inferred from physical interaction
11329063 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11329063 GOA
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
11329063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCN2 Protein Structure

(72 - 109)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

urocortin-2

  • prepro-urocortin 2

Related Diseases

Diseases Alias
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15408 UCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15583 UTS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20833 Uts2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27347 Uts2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UCN2 VGNC VGNC:36638
Canis familiaris UCN2 VGNC VGNC:48109
Rattus norvegicus UCN2 RGD RGD:620765
Mus musculus UCN2 MGD MGI:2176375
Others UCN2 NCBI