ANGPTL1 - angiopoietin like 1 Gene

Also Known as ANG3; ARP1; AngY; ANGPT3; UNQ162; dJ595C2.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9068

About ANGPTL1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:178,849,535-178,871,077 (from NCBI)

This gene has 3 transcripts (splice variants), 284 orthologues and 25 paralogues. Broad expression in ovary (RPKM 20.0), placenta (RPKM 16.0) and 21 other tissues.

Summary

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and Angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

ANGPTL1 Products (2)

mRNA Protein Name
NM_001376763.1 NP_001363692.1 angiopoietin-related protein 1 precursor
NM_004673.4 NP_004664.1 angiopoietin-related protein 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10025962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL1 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (278 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

angiopoietin-related protein 1

  • ANG-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00690 ANGPTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21225 Angptl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27741 Angptl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANGPTL1 VGNC VGNC:25890
Canis familiaris ANGPTL1 VGNC VGNC:37857
Mus musculus ANGPTL1 MGD MGI:1919963
Felis catus ANGPTL1 VGNC VGNC:67562
Macaca mulatta ANGPTL1 VGNC VGNC:69813
Rattus norvegicus ANGPTL1 RGD RGD:1598128
Others ANGPTL1 NCBI