ESAM - endothelial cell adhesion molecule Gene

Also Known as W117m

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90952

About ESAM

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,753,126-124,762,290 (from NCBI)

This gene has 6 transcripts (splice variants), 292 orthologues and 14 paralogues. Broad expression in placenta (RPKM 71.1), thyroid (RPKM 67.5) and 21 other tissues.

Summary

Enables cell-cell adhesion mediator activity. Involved in several processes, including bicellular tight junction assembly; cell-cell adhesion; and regulation of actin Cytoskeleton organization. Located in cell-cell junction and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

ESAM Products (1)

mRNA	Protein	Name
NM_138961.3	NP_620411.2	endothelial cell-selective adhesion molecule precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell-cell adhesion mediator activity	IDA IDA: Inferred from direct assay	20298433	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26607202	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	26607202	GOA
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	20298433	GOA
involved in protein localization	IDA IDA: Inferred from direct assay	20298433	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	20298433	GOA
involved in regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	20298433	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	20298433	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20298433	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26607202	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESAM Protein Structure

V-set

Ig_2

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
endothelial cell-selective adhesion molecule	2310008D05Rik

Recombinant ESAM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70889	ESAM Protein, Human (HEK293, His)	Q96AP7-1 (Q30-A247 )	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Aqueous Misdirection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04520	ESAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18130	Esam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24604	Esam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ESAM	VGNC	VGNC:53356
Macaca mulatta	ESAM	VGNC	VGNC:72290
Rattus norvegicus	ESAM	RGD	RGD:1303286
Felis catus	ESAM	VGNC	VGNC:102878
Mus musculus	ESAM	MGD	MGI:1916774
Bos taurus	ESAM	VGNC	VGNC:50042
Others	ESAM	NCBI