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SLC16A4 - solute carrier family 16 member 4 Gene

Also Known as MCT4; MCT5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9122

About SLC16A4

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,362,857-110,391,026 (from NCBI)

This gene has 10 transcripts (splice variants), 244 orthologues and 13 paralogues. Biased expression in kidney (RPKM 44.3), placenta (RPKM 12.3) and 10 other tissues.

Summary

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC16A4 Products (6)

mRNA	Protein	Name
NM_001201546.2	NP_001188475.1	monocarboxylate transporter 5 isoform 2
NM_001201547.2	NP_001188476.1	monocarboxylate transporter 5 isoform 3
NM_001201548.2	NP_001188477.1	monocarboxylate transporter 5 isoform 4
NM_001201549.2	NP_001188478.1	monocarboxylate transporter 5 isoform 5
NM_001319220.2	NP_001306149.1	monocarboxylate transporter 5 isoform 6
NM_004696.3	NP_004687.1	monocarboxylate transporter 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A4 Protein Structure

MFS_1

0
100
200
300
400
487 a.a.

Protein Preferred Names	Protein Names
monocarboxylate transporter 5	MCT 4

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Pharynx Squamous Cell Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13026	SLC16A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC16A4	VGNC	VGNC:65211
Mus musculus	SLC16A4	MGD	MGI:2385183
Bos taurus	SLC16A4	VGNC	VGNC:34690
Rattus norvegicus	SLC16A4	RGD	RGD:1359655
Canis familiaris	SLC16A4	VGNC	VGNC:46243
Macaca mulatta	SLC16A4	VGNC	VGNC:77398
Others	SLC16A4	NCBI