COX7A2L - cytochrome c oxidase subunit 7A2 like Gene

Also Known as EB1; SCAF1; SCAFI; SIG81; COX7AR; COX7RP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9167

About COX7A2L

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,335,559-42,368,957 (from NCBI)

This gene has 8 transcripts (splice variants), 270 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 37.4), kidney (RPKM 24.0) and 25 other tissues.

Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast Cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and Others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

COX7A2L Products (5)

mRNA Protein Name
NM_001319036.1 NP_001305965.1 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform a
NM_001319037.1 NP_001305966.1 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform b
NM_001319038.2 NP_001305967.1 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform c
NM_001319040.2 NP_001305969.1 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform d
NM_004718.4 NP_004709.2 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform a

COX7A2L Protein Structure

COX7a

COX7a: Cytochrome c oxidase subunit VII (57 - 113)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

cytochrome c oxidase subunit 7A-related protein, mitochondrial

  • COX7a-related protein

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03075 COX7A2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COX7A2L RGD RGD:1306111
Canis familiaris COX7A2L VGNC VGNC:39541
Mus musculus COX7A2L MGD MGI:106015
Felis catus COX7A2L VGNC VGNC:80075
Bos taurus COX7A2L VGNC VGNC:27640
Others COX7A2L NCBI