DPH7 - diphthamide biosynthesis 7 Gene

Homo sapiens

Also known as RRT2; WDR85; C9orf112

Gene ID: 92715 | Gene type: protein coding

About DPH7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,554,444-137,578,925 (from NCBI)

This gene has 14 transcripts (splice variants) and 168 orthologues. Ubiquitous expression in testis (RPKM 4.1), spleen (RPKM 3.9) and 25 other tissues.

Summary

Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]

DPH7 Products(28)

mRNA	Protein	Name
NM_001346370.2	NP_001333299.1	diphthine methyltransferase isoform b
NM_001346371.2	NP_001333300.1	diphthine methyltransferase isoform c
NM_001346372.2	NP_001333301.1	diphthine methyltransferase isoform d
NM_001346373.2	NP_001333302.1	diphthine methyltransferase isoform e
NM_001346374.2	NP_001333303.1	diphthine methyltransferase isoform f
NM_001346375.2	NP_001333304.1	diphthine methyltransferase isoform g
NM_001346376.2	NP_001333305.1	diphthine methyltransferase isoform g
NM_001346377.2	NP_001333306.1	diphthine methyltransferase isoform g
NM_001346378.2	NP_001333307.1	diphthine methyltransferase isoform g
NM_001346379.2	NP_001333308.1	diphthine methyltransferase isoform g
NM_001346380.2	NP_001333309.1	diphthine methyltransferase isoform g
NM_001346381.2	NP_001333310.1	diphthine methyltransferase isoform g
NM_001346382.2	NP_001333311.1	diphthine methyltransferase isoform g
NM_001346383.2	NP_001333312.1	diphthine methyltransferase isoform g
NM_001346384.2	NP_001333313.1	diphthine methyltransferase isoform g
NM_001346385.2	NP_001333314.1	diphthine methyltransferase isoform g
NM_001346386.2	NP_001333315.1	diphthine methyltransferase isoform g
NM_001346387.2	NP_001333316.1	diphthine methyltransferase isoform g
NM_001346388.2	NP_001333317.1	diphthine methyltransferase isoform g
NM_001346389.2	NP_001333318.1	diphthine methyltransferase isoform g
NM_001346390.2	NP_001333319.1	diphthine methyltransferase isoform g
NM_001346391.2	NP_001333320.1	diphthine methyltransferase isoform g
NM_001346392.2	NP_001333321.1	diphthine methyltransferase isoform g
NM_001346393.2	NP_001333322.1	diphthine methyltransferase isoform h
NM_001346394.2	NP_001333323.1	diphthine methyltransferase isoform h
NM_001346395.2	NP_001333324.1	diphthine methyltransferase isoform h
NM_001346396.2	NP_001333325.1	diphthine methyltransferase isoform h
NM_138778.5	NP_620133.1	diphthine methyltransferase isoform a

DPH7 Protein Structure

WD40

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

diphthine methyltransferase

WD repeat-containing protein 85

Related Diseases

Diseases

Alias

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Gaucher Disease, Type Iiic

Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome	Gaucher-Like Disease
GD3C	Gaucher'S Disease Type Iiic
Cardiovascular Gaucher Disease	Gaucher Disease Type 3c
Gaucher Disease 3c	Pseudo-Gaucher Disease

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03957	DPH7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DPH7	VGNC	VGNC:53234
Rattus norvegicus	DPH7	RGD	RGD:1304868
Mus musculus	DPH7	MGD	MGI:1914478
Macaca mulatta	DPH7	VGNC	VGNC:71904
Bos taurus	DPH7	VGNC	VGNC:28182
Felis catus	DPH7	VGNC	VGNC:61599