TM9SF2 - transmembrane 9 superfamily member 2 Gene

Also Known as P76

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9375

About TM9SF2

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,501,472-99,564,048 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 79.3), colon (RPKM 75.9) and 25 other tissues.

Summary

This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]

TM9SF2 Products (1)

mRNA Protein Name
NM_004800.3 NP_004791.1 transmembrane 9 superfamily member 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IMP
IMP: Inferred from mutant phenotype
30660999 GOA
involved in glycosphingolipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
30660999 GOA
involved in regulation of heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
28404855 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
28404855 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM9SF2 Protein Structure

EMP70

EMP70: Endomembrane protein 70 (74 - 620)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

transmembrane 9 superfamily member 2

  • 76 kDa membrane protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14613 TM9SF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21957 Tm9sf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28474 Tm9sf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TM9SF2 VGNC VGNC:53839
Canis familiaris TM9SF2 VGNC VGNC:47415
Rattus norvegicus TM9SF2 RGD RGD:1359230
Macaca mulatta TM9SF2 VGNC VGNC:78568
Felis catus TM9SF2 VGNC VGNC:66228
Mus musculus TM9SF2 MGD MGI:1915309
Others TM9SF2 NCBI