Cers1 - ceramide synthase 1 Gene

Also Known as to; Lass1; Uog-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 93898

Summary

This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of Sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Mice lacking a functional copy of this gene exhibit impaired cerebellar development, locomotion and motor coordination. This protein is transcribed from a bicistronic mRNA, which also encodes Growth Differentiation Factor 1. [provided by RefSeq, Jul 2016]

Cers1 Products (1)

mRNA Protein Name
NM_138647.3 NP_619588.1 ceramide synthase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
21625621 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26620563 MGI
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
16951403 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
15248193 MGI
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
16951403 MGI
involved in ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
21625621 MGI
involved in negative regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
30605666 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
16951403 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ceramide synthase 1

  • LAG1 homolog, ceramide synthase 1

  • LAG1 longevity assurance homolog 1

  • longevity assurance gene 1 protein homolog 1

  • longevity assurance homolog 1

  • protein UOG-1

  • sphingoid base N-stearoyltransferase CERS1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126015 P053 Inhibitor 97.0% Unkown
HY-120803 Mefluidide 99.81% Unkown
HY-146910S CER1 (d18:1/26:0/18:1)-d9 99.0% Unkown
HY-176568 LCL768 / Unkown
HY-N15835 CER1(d18:1/28:0/18:2) / Unkown
HY-RS02532 CER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02536 CERS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05349 GDF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175198 Cs-2d Inhibitor / Unkown
HY-179832 CER1 (d18:1/26:0/18:1) / Unkown
HY-RS18128 Cer1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19995 Cers1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24602 Cer1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26499 Cers1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cers1 NCBI NCBI:10715