2. Gene
  3. CPA5 - carboxypeptidase A5 Gene

CPA5 - carboxypeptidase A5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 93979 | Gene type: protein coding

About CPA5

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,344,816-130,374,599 (from NCBI)

This gene has 11 transcripts (splice variants), 145 orthologues and 8 paralogues. Restricted expression toward testis (RPKM 7.8).

Summary

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine Peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active Carboxypeptidase domain. Cleavage of the pro region activates the Enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

CPA5 Products(4)

mRNA Protein Name
NM_001127441.2 NP_001120913.1 carboxypeptidase A5 isoform 1 precursor
NM_001127442.2 NP_001120914.1 carboxypeptidase A5 isoform 2 precursor
NM_001318223.2 NP_001305152.1 carboxypeptidase A5 isoform 1 precursor
NM_080385.5 NP_525124.3 carboxypeptidase A5 isoform 1 precursor

CPA5 Protein Structure

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (43 - 118)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (145 - 422)

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  • 436 a.a.
Protein Preferred Names Protein Names

carboxypeptidase A5

testicular tissue protein Li 32

Related Diseases

Diseases Alias
Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03084 CPA5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPA5 VGNC VGNC:61115
Bos taurus CPA5 VGNC VGNC:107221
Canis familiaris CPA5 VGNC VGNC:39546
Rattus norvegicus CPA5 RGD RGD:1303098
Mus musculus CPA5 MGD MGI:1921899
Macaca mulatta CPA5 VGNC VGNC:71410