ABCC12 - ATP binding cassette subfamily C member 12 Gene

Also Known as MRP9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94160

About ABCC12

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:48,080,882-48,155,993 (from NCBI)

This gene has 14 transcripts (splice variants), 224 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 3.1).

Summary

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast Cancer. [provided by RefSeq, Jul 2008]

ABCC12 Products (5)

mRNA Protein Name
NM_001392028.1 NP_001378957.1 ATP-binding cassette sub-family C member 12 isoform 2
NM_001393797.1 NP_001380726.1 ATP-binding cassette sub-family C member 12 isoform 3
NM_001393798.1 NP_001380727.1 ATP-binding cassette sub-family C member 12 isoform 4
NM_001393799.1 NP_001380728.1 ATP-binding cassette sub-family C member 12 isoform 5
NM_033226.3 NP_150229.2 ATP-binding cassette sub-family C member 12 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17472575 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCC12 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (125 - 389)

ABC_tran

ABC_tran: ABC transporter (496 - 630)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (796 - 1012)

ABC_tran

ABC_tran: ABC transporter (1137 - 1285)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1359 a.a.
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 12

  • ATP-binding cassette transporter sub-family C member 12

Related Diseases

Diseases Alias
Episodic Kinesigenic Dyskinesia 1

  • Paroxysmal Kinesigenic Choreoathetosis

  • Paroxysmal Kinesigenic Dyskinesia

  • Dystonia 10

  • Familial Paroxysmal Kinesigenic Dyskinesia

  • Episodic Kinesigenic Dyskinesia

  • EKD1

  • Pkc

  • Pkd

  • Dyt10

  • Familial Pkd

  • Paroxysmal Kinesigenic Choreathetosis

  • Familial Paroxysmal Dystonia

  • Dystonia, Familial Paroxysmal

  • Dyt-Prrt2

  • Dystonia, Type 10
Dubin-Johnson Syndrome

  • DJS

  • Chronic Idiopathic Jaundice

  • Jaundice, Chronic Idiopathic

  • Hyperbilirubinemia, Dubin-Johnson Type

  • Hyperbilirubinemia Ii

  • Hyperbilirubinemia Type 2

  • Conjugated Hyperbilirubinemia

  • Dubin-Sprinz Disease

  • Sprinz-Nelson Syndrome

  • Hblrdj

  • Dubin Johnson Syndrome

  • Hyperbilirubinemia 2

  • Black Liver-Jaundice Syndrome

  • Chronic Idiopathic Jaundice With Pigmented Liver

  • Dubin-Sprinz Syndrome

  • Hyperbilirubinaemia Type 2

  • Djs - [Dubin-Johnson Syndrome]
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00060 ABCC12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ABCC12 VGNC VGNC:59470
Mus musculus ABCC12 MGD MGI:2441679
Bos taurus ABCC12 VGNC VGNC:25471
Macaca mulatta ABCC12 VGNC VGNC:69404
Rattus norvegicus ABCC12 RGD RGD:735100
Canis familiaris ABCC12 VGNC VGNC:37439
Others ABCC12 NCBI