Mcoln1 - mucolipin 1 Gene

Also Known as TRPML1; mucolipidin; 2210015I05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94178

Summary

Enables intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity. Involved in several processes, including cellular response to calcium ion; cellular response to pH; and protein homotetramerization. Acts upstream of or within autophagosome maturation. Is integral component of membrane. Is active in intracellular vesicle. Is expressed in several structures, including cochlea; genitourinary system; liver; lung; and spleen. Used to study mucolipidosis type IV. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Orthologous to human MCOLN1 (mucolipin TRP cation channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Mcoln1 Products (1)

mRNA Protein Name
NM_053177.1 NP_444407.1 mucolipin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
17989217 MGI
enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity IDA
IDA: Inferred from direct assay
29019981 MGI
enables iron ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
18794901 MGI
enables monoatomic anion channel activity IDA
IDA: Inferred from direct assay
17989217 MGI
enables potassium channel activity IDA
IDA: Inferred from direct assay
17989217 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25130899 MGI
enables sodium channel activity IDA
IDA: Inferred from direct assay
17989217 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagosome maturation IMP
IMP: Inferred from mutant phenotype
20600908 MGI
involved in cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
29019981 MGI
involved in cellular response to pH IMP
IMP: Inferred from mutant phenotype
29019981 MGI
involved in iron ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18794901 MGI
involved in monoatomic cation transmembrane transport IDA
IDA: Inferred from direct assay
29019981 MGI
involved in phagosome maturation IDA
IDA: Inferred from direct assay
27623384 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
29019981 MGI
Cellular Component GO Annotation Evidence References Source
is active in intracellular vesicle EXP
EXP: Inferred from Experiment
25130899 MGI
located in membrane IDA
IDA: Inferred from direct assay
29019981 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucolipin-1

  • transient receptor potential-mucolipin 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08244 MCOLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20178 Mcoln1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26682 Mcoln1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcoln1 NCBI NCBI:57192