AKAP6 - A-kinase anchoring protein 6 Gene

Also Known as ADAP6; PRKA6; mAKAP; ADAP100; AKAP100

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9472

About AKAP6

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,329,298-32,837,684 (from NCBI)

This gene has 15 transcripts (splice variants), 204 orthologues and 1 paralogue. Biased expression in brain (RPKM 9.8), heart (RPKM 7.6) and 12 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

AKAP6 Products (1)

mRNA Protein Name
NM_004274.5 NP_004265.3 A-kinase anchor protein 6
Protein Preferred Names Protein Names

A-kinase anchor protein 6

  • A kinase (PRKA) anchor protein 6

Related Diseases

Diseases Alias
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

  • Catecholaminergic Polymorphic Ventricular Tachycardia 2

  • CPVT2

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Cvpt2

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • CPVT1

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt1

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Ventricular Tachycardia Catecholaminergic Polymorphic 1

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Long Qt Syndrome 1

  • Romano-Ward Syndrome

  • LQT1

  • Ward-Romano Syndrome

  • Rws

  • Ventricular Fibrillation With Prolonged Qt Interval

  • Wrs

  • Long Qt Syndrome 1, Acquired, Susceptibility To

  • Long Qt Syndrome 1, Acquired

  • Romano-Ward Long Qt Syndrome

  • Long Qt Syndrome Type 1

  • Long Qt Syndrome-1

  • Acquired Susceptibility To Long Qt Syndrome 1

  • Qt Syndrome, Long, Type 1
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00521 AKAP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22383 Akap6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28907 Akap6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AKAP6 VGNC VGNC:25787
Macaca mulatta AKAP6 VGNC VGNC:69771
Canis familiaris AKAP6 VGNC VGNC:37759
Mus musculus AKAP6 MGD MGI:3050566
Felis catus AKAP6 VGNC VGNC:59716
Rattus norvegicus AKAP6 RGD RGD:69412
Others AKAP6 NCBI