PGS1 - phosphatidylglycerophosphate synthase 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9489

About PGS1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,378,649-78,424,659 (from NCBI)

This gene has 15 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in bone marrow (RPKM 9.6), appendix (RPKM 8.4) and 25 other tissues.

Summary

Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

PGS1 Products (1)

mRNA Protein Name
NM_024419.5 NP_077733.3 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
38322995 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGS1 Protein Structure

PLDc_2

PLDc_2: PLD-like domain (111 - 259)

  • 0
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  • 200
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  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

  • PGP synthase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01489 BGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10401 PGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18113 Bgn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PGS1 VGNC VGNC:64127
Rattus norvegicus PGS1 RGD RGD:1305052
Bos taurus PGS1 VGNC VGNC:32803
Macaca mulatta PGS1 VGNC VGNC:75890
Canis familiaris PGS1 VGNC VGNC:44472
Mus musculus PGS1 MGD MGI:1921701
Others PGS1 NCBI