CXCL14 - C-X-C motif chemokine ligand 14 Gene

Also Known as KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9547

About CXCL14

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,570,679-135,578,991 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in skin (RPKM 295.1), kidney (RPKM 161.0) and 13 other tissues.

Summary

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

CXCL14 Products (1)

mRNA Protein Name
NM_004887.5 NP_004878.3 C-X-C motif chemokine 14 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12949249 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12949249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL14 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (35 - 97)

  • 0
  • 100
  • 111 a.a.
Protein Preferred Names Protein Names

C-X-C motif chemokine 14

  • CXC chemokine in breast and kidney

CXCL14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CXCL14 O95715 PF4 Homo sapiens P02776
SPR
28381538
Intra
CXCL14 O95715 PF4 Homo sapiens P02776
Filter Binding
28381538
Intra
CXCL14 O95715 CCL5 Homo sapiens P13501
SPR
28381538
Intra
CXCL14 O95715 CCL5 Homo sapiens P13501
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL11 Homo sapiens O14625
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL9 Homo sapiens Q07325
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL12 Homo sapiens P48061
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
CXCL14 O95715 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
CXCL14 O95715 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
Intra
CXCL14 O95715 CCL21 Homo sapiens O00585
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL14 Proteins

Cat. No. Product Name Accession Purity
HY-P72683 CXCL14/BRAK Protein, Human O95715 (S35-E111) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75315 CXCL14/BRAK Protein, Human (Biotinylated) O95715 (S35-E111) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cervical Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Cervix Uteri

  • Squamous Cell Carcinoma Of Cervix
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03388 CXCL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17348 Cxcl14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23802 Cxcl14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CXCL14 VGNC VGNC:39748
Rattus norvegicus CXCL14 RGD RGD:1307406
Felis catus CXCL14 VGNC VGNC:61297
Macaca mulatta CXCL14 VGNC VGNC:71394
Bos taurus CXCL14 VGNC VGNC:27850
Mus musculus CXCL14 MGD MGI:1888514
Others CXCL14 NCBI