ZNF536 - zinc finger protein 536 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9745

About ZNF536

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:30,225,592-30,713,586 (from NCBI)

This gene has 14 transcripts (splice variants), 258 orthologues and 14 paralogues. Biased expression in brain (RPKM 2.6), thyroid (RPKM 0.8) and 11 other tissues.

Summary

The protein encoded by this gene is a highly conserved Zinc Finger Protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

ZNF536 Products (4)

mRNA Protein Name
NM_001352260.2 NP_001339189.1 zinc finger protein 536 isoform 2
NM_001376110.1 NP_001363039.1 zinc finger protein 536 isoform 3
NM_001376111.1 NP_001363040.1 zinc finger protein 536 isoform 3
NM_014717.3 NP_055532.1 zinc finger protein 536 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19398580 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19398580 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19398580 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF536 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (145 - 166)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (274 - 297)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (300 - 323)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (345 - 367)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (373 - 395)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (632 - 653)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (765 - 788)

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  • 1300 a.a.
Protein Preferred Names Protein Names

zinc finger protein 536

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16152 ZNF536 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF536 MGD MGI:1926102
Rattus norvegicus ZNF536 RGD RGD:1563363
Bos taurus ZNF536 VGNC VGNC:37299
Canis familiaris ZNF536 VGNC VGNC:48756
Felis catus ZNF536 VGNC VGNC:67325
Others ZNF536 NCBI