CDC34 - cell division cycle 34, ubiqiutin conjugating enzyme Gene

Also Known as UBC3; UBCH3; UBE2R1; E2-CDC34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 997

About CDC34

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:531,760-542,087 (from NCBI)

This gene has 7 transcripts (splice variants), 126 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to Other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

CDC34 Products (1)

mRNA Protein Name
NM_004359.2 NP_004350.1 ubiquitin-conjugating enzyme E2 R1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10373550 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
20061386 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
10373550 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to interferon-beta IMP
IMP: Inferred from mutant phenotype
24882218 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
10373550 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
20347421 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
10373550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC34 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (14 - 154)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 R1

  • (E3-independent) E2 ubiquitin-conjugating enzyme R1

CDC34 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC34 P49427 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CDC34 P49427 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CDC34 P49427 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CDC34 P49427 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
CDC34 P49427 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
CDC34 P49427 MEOX1 Homo sapiens P50221
Validated Y2H
32296183
Intra
CDC34 P49427 CUL1 Homo sapiens Q13616
FRET
19945379
Intra
CDC34 P49427 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
CDC34 P49427 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
CDC34 P49427 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
CDC34 P49427 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDC34 Proteins

Cat. No. Product Name Accession Purity
HY-P79448 UBE2R1/CDC34 Protein, Human (sf9, His, StrepII) P49427 (A2-S236) ≥ 90%, as determined by reducing SDS-PAGE.

CDC34 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83041 CDC34 Antibody (YA2786) WB, IP Human, Mouse, Rat
HY-P83041A CDC34 Antibody (YA2786)(PBS only) WB, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15301 CC0651 Inhibitor 98.83% Unkown
HY-RS02296 CDC34 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22424 Cdc34 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28947 Cdc34 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC34 VGNC VGNC:60654
Mus musculus CDC34 MGD MGI:102657
Bos taurus CDC34 VGNC VGNC:27066
Rattus norvegicus CDC34 RGD RGD:1305411
Canis familiaris CDC34 VGNC VGNC:38993
Macaca mulatta CDC34 VGNC VGNC:108493
Others CDC34 NCBI