hCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC50=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2971782-73-5
- Formula: C24H28N6O6S
- Molecular Weight:528.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 358 nM (VEGFR-2), 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII)[1]
Chemical Information
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CAS No. 2971782-73-5
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Molecular Weight 528.58
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Formula C24H28N6O6S
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SMILES
CC(N1CC(C(N/N=C2C(NC3=C\2C=C(OC)C=C3)=O)=O)CCC1)C(NC4=CC=C(S(=O)(N)=O)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCA/VEGFR-2-IN-3 Related Classifications
HY-155760 Related Classifications
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