Diuvaretin
Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria.
For research use only. We do not sell to patients.
- CAS No.: 61463-04-5
- Formula: C30H28O6
- Molecular Weight:484.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Caspase-3 |
Plasmodium |
Diuvaretin (48 h) potently inhibits the proliferation of promyelocytic leukemia HL-60 cells, with an IC50 value of 6.1 μM[1].
Diuvaretin (10-20 μM; 24-48 h) induces morphological changes of apoptosis (chromatin condensation and nuclear degradation) in promyelocytic leukemia HL-60 cells[1].
Diuvaretin (5-20 μM; 6-24 h) induces G1 phase arrest and sub-G1 peak formation in promyelocytic leukemia HL-60 cells, while 5 μM Diuvaretin has no effect on cell cycle distribution[1].
Diuvaretin inhibits the growth of Plasmodium falciparum with an IC50 of 3.5 mg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:dose-response
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Incubation Time:48 h
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Result:Exhibited dose-dependent growth inhibition of HL-60 cells, with an IC50 value of 6.1 μM.
Showed stronger cytotoxicity than isouvaretin and slightly stronger cytotoxicity than uvaretin.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:6 h, 12 h, 24 h
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Result:Induced accumulation of cells in the G1 phase and the appearance of a sub-G1 peak (indicative of apoptotic cells) at 10 μM or 20 μM for 12 h or 24 h.
Showed no cell cycle changes with 5 μM across 6-24 h incubation times.
Chemical Information
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CAS No. 61463-04-5
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Molecular Weight 484.55
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Formula C30H28O6
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SMILES
O=C(C=1C(O)=C(C(O)=C(C1OC)CC=2C=CC=CC2O)CC=3C=CC=CC3O)CCC=4C=CC=CC4
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nakatani N, et al. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull. 2005 Jan;28(1):83-6. [Content Brief]
[2]. Makangara JJ, et al. A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Nat Prod Lett. 2002;16(4):267-272. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diuvaretin Related Classifications
HY-N13034 Related Classifications
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