2′-Hydroxy-2,3-dimethoxychalcone
α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells.
For research use only. We do not sell to patients.
- CAS No.: 42220-80-4
- Formula: C17H16O4
- Molecular Weight:284.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780cisR | GI50 |
14.38 μM
Compound: 4
|
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
|
[PMID: 24565968] |
| RAW264.7 | IC50 |
3.8 μM
Compound: 15
|
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
|
[PMID: 19233646] |
Chemical Information
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CAS No. 42220-80-4
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Molecular Weight 284.31
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Formula C17H16O4
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SMILES
O=C(C1=C(O)C=CC=C1)/C=C/C2=C(OC)C(OC)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)