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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
Urease Inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "Urease Inhibitor" in MCE Product Catalog:
Cat. No.: HY-161860
Antibacterial agent 233 (Compound 7c) exhibits inhibitory efficacy against Helicobacter pylori with MIC of 0.4-1.6 μg/mL. Antibacterial agent 233 inhibits jack bean urease (IC50 is 0.27 μg/mL), changes the permeability of H. pylori cell membrane, causes the leakage of cellular contents. Antibacterial agent 233 exhibits metabolic stability in whole blood and artificial gastric fluid. Antibacterial agent 233 exhibits antitumor efficacy against U2OS in mice .
Cat. No.: HY-173428
Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
Cat. No.: HY-184981
CAS No.: 2243516-99-4
Urease-IN-24 is a cryptococcal urease inhibitor with a IC50 of 89.96 nM and a Ki of 64.3 nM. Urease-IN-24 acts as a competitive nickel-coordinating inhibitor that coordinates with the nickel center at the catalytic site of the enzyme via its carbonyl group. Urease-IN-24 reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases cell membrane permeability, and inhibits melanin production. Urease-IN-24 exhibits fungicidal activity against Cryptococcus species. Urease-IN-24 can be used in the research of cryptococcosis .
Cat. No.: HY-181149
Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC50 of 8.20 μM, thymidine phosphorylase IC50 of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer .
Cat. No.: HY-184980
CAS No.: 2180967-88-6
Urease-IN-23 is a cryptococcal urease inhibitor with antifungal activity. AF55 exhibits mixed-type inhibition against cryptococcal urease, binds to both the nickel ion site at the enzyme's catalytic center and the allosteric site, impairs urease catalytic efficiency, simultaneously disrupts fungal virulence structures and damages cell membrane integrity. The IC50 and Ki values of Urease-IN-23 against cryptococcal urease are 54.92 nM and 149.1 nM, respectively. Urease-IN-23 significantly reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases fungal cell membrane permeability, and completely blocks melanin synthesis. Urease-IN-23 shows no toxicity in the Galleria mellonella larval model. Urease-IN-23 can be used in studies related to fungal infections .
Cat. No.: HY-187186
CAS No.: 115037-71-3
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Urease-IN-25 (Compound 10a) is a urease inhibitor with an IC50 value of 0.50 μM against jack bean urease. Urease-IN-25 can be used in the research of Helicobacter pylori infection, chronic gastritis, peptic ulcer disease, gastric cancer, mucosa-associated lymphoid tissue lymphoma, and other conditions .
Cat. No.: HY-189733
CAS No.: 60945-03-1
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NK037 is a phthalimide derivative that exhibits multi-target enzyme inhibitory activity against urease, xanthine oxidase, and butyrylcholinesterase (BChE). NK037 inhibits urease with IC50 = 2.9 μM, xanthine oxidase with IC50 = 5.61 μM, and butyrylcholinesterase with IC50 = 9.49 μM. NK037 can form enzyme-ligand complexes with urease, xanthine oxidase, and thymidine phosphorylase. Urease-IN-26 can be used for metabolism-related research .
Cat. No.: HY-186298
CAS No.: 73691-63-1
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Cat. No.: HY-107199R
CAS No.: 94317-64-3
Synonyms: NBPT (Standard)
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N-Butylthiophosphoric triamide (Standard) (NBPT (Standard)) is the analytical standard of N-Butylthiophosphoric triamide (HY-107199). This product is intended for research and analytical applications. N-Butylthiophosphoric triamide (NBPT) is a potent urease inhibitor. Butylthiophosphoric triamide inhibits nitrification and reduces the conversion of urea to NH3 gas .
CCPD-Q (CCPD-Quinone) is a quinone derivative of phenylenediamine-based tire wear compounds, as well as a Urease inhibitor against Helicobacter pylori, with an IC50 value of 41.50 μM. CCPD-Q can be used in studies related to Helicobacter pylori infection .
Cat. No.: HY-W207687
CAS No.: 4506-62-1
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Thymidine phosphorylase-IN-1 (compound C17) is a potent Thymidine phosphorylase inhibitor with an IC50 of 3.24 μM. Thymidine phosphorylase-IN-1 exhibits high binding affinity for Urease and Xanthine oxidase, with Kd values of 0.02 and 0.15 μM, respectively. Thymidine phosphorylase-IN-1 achieves optimal geometric complementarity and stable binding with the catalytic site of the target enzyme through hydrogen bonding, hydrophobic interactions, and π-π stacking mediated by the aminophenyl nitrogen atom. Thymidine phosphorylase-IN-1 can be used for research on tuberculosis .
Cat. No.: HY-187201
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Antimicrobial agent-54 is a ciprofloxacin-derived multi-target antimicrobial agent that inhibits E. coli DNA gyrase, S. aureus topoisomerase IV, LpxC and urease with IC50 values of 0.182, 3.501, 0.052 and 6.254 μM, respectively. The MIC of Antimicrobial agent-54 against E. coli ATCC 8739 is 0.20 μM. Antimicrobial agent-54 interferes with bacterial cell division, causes transient membrane disruption in Gram-positive bacteria, and induces aberrant penicillin-binding protein activity in Gram-negative bacteria. Antimicrobial agent-54 can be used in the research of bacterial infections, including multidrug-resistant bacterial infections and mycobacterial infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
